Circulating micromegakaryocytes in myelodysplasia.

Identification of circulating micromegakaryocytes in a case of refractory anemia: an electron microscopic-cytochemical study.

Identification of Circulating Micromegakaryocytes in a Case of Refractory Anemia

In a case of refractory anemia with an excess of myeloblasts in the bone marrow and with thrombocytopenia, examinations of the blood cells under the electron microscope have revealed nucleated cells similar in size to small lymphocytes. Some of these lymphocytelike cells have scanty cytoplasm identical to that of giant platelets present in the blood, which re pathologic in view of their highly ...

203-206 A Case With Microme.QXD

A boy with no previous history of bleeding presented with ecchymoses and splenomegaly. He was followed up for thrombocytopenia and micromegakaryocytes for 20 months till clinically malignancy was diagnosed. Micromegakaryocytes must always be treated with suspicion, as they may provide an important clue for dyshematopoesis.

Peripheral blood picture in primary hypocellular refractory anemia and idiopathic acquired aplastic anemia: an additional tool for differential diagnosis.

BACKGROUND AND OBJECTIVE Hypoplastic myelodysplastic syndromes (MDS) are being reported with increasing frequency. Aplastic anemia (AA) needs to be differentiated from hypoplastic MDS particularly primary hypoplastic refractory anemia (PHRA) because of the impact on management and prognosis. This distinction may be morphologically difficult even with careful marrow examination which may provide...

Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes.

Although aplastic anemia and myelodysplasia have been extensively investigated, little is known about their circulating cytokine patterns. We compared plasma soluble cytokines in 33 aplastic anemia, 57 myelodysplasia patients, and 48 healthy controls. High levels of thrombopoietin and granulocyte colony-stimulating factor, with low levels of CD40 ligand, chemokine (C-X-C motif) ligand 5, chemok...